Mutual interaction of lncRNAs and epigenetics: focusing on cancer

Abstract Long noncoding RNAs are characterized as transcripts longer than 200 nucleotides in response to a variety of functions within the cells. They involved almost all cellular mechanisms so epigenetics. Given that epigenetics is an important phenomenon, which participates biology complex diseases, many valuable studies have been performed demonstrate control status lncRNAs and DNA methylation histone modifications epigenetic can regulate expression by affecting their coding genes. Reciprocally, three-dimensional structure could mechanistically activity epigenetic-related enzymes. Dysregulation mutual interaction between one hallmarks cancer. These either directly or indirectly various cancer properties such proliferation, apoptosis, invasion, metastasis. For instance, lncRNA HOTAIR plays role regulating genes interacting with factors methyltransferases EZH2, thus initiation progression cancers. Conversely, this also controlled factors. Therefore, focusing on reciprocated apply management identification prognostic, diagnostic, druggable targets. In current review, we discuss reciprocal relationship promote prevent find new potent biomarkers targets for diagnosis therapy.